Halal Research Center of Islamic Republic of Iran. Tel.: +98-21-88909033 Fax: +98-21-88890858 Email: jhhhm@halal.ac.ir IR.MCIG No. 85915 Human, Health and Halal Metrics 2717-1027 4 1 2023 05 01 Tuberculosis lymphadenitis: An unusual swelling of salivary glands, a case series study in Iran 14 21 176944 10.30502/jhhhm.2023.363334.1060 EN Ehsan Amini-Salehi Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Soheil Hassanipour Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Tofigh Yaghubi Kalurazi Department of Health, Nutrition & Infectious Diseases, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Farahnaz Joukar Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. 0000-0001-8432-8879 Ahmad Jabarouti Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Mohammad Shafipour Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Rastin Nikkar Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Majid Asgharzadeh Department of Health, Nutrition & Infectious Diseases, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Seyedeh Amineh Hojati Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. 0000-0002-6677-8793 Fariborz Mansour-Ghanaei Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. 0000-0002-6264-0025 Journal Article 2022 10 13 <strong>Background and objective:</strong> Tuberculosis is a chronic granulomatous infection and has become a global concern. This disease is caused by <em>Mycobacterium tuberculosis</em>, but other types of Mycobacterium can also cause the disease. Tuberculosis usually affects the respiratory system, but other organs, called extrapulmonary tuberculosis, can be involved. Lymph node tuberculosis is one of the manifestations of extrapulmonary tuberculosis, especially in regions where tuberculosis is endemic. The involvement of salivary glands with tuberculosis is an uncommon condition. Here we present three cases (two adults and one child) with tuberculosis salivary gland lymphadenitis.<br /><strong>Results and conclusion:</strong> In all the cases, tuberculosis diagnosis was confirmed by biopsy. Although, the diagnosis of tuberculosis was easier in the child due to symptoms like night sweating and fever and positive purified protein derivative test, in adults, there were no abnormalities in the initial laboratory tests, and purified protein derivative tests were negative, which made the diagnosis of tuberculosis more complicated. Although, salivary gland involvement with tuberculosis is not common, it should be considered a differential diagnosis in patients with swelling of salivary glands. In addition, the diagnosis confirmation should be based on biopsy, and normal laboratory tests and negative purified protein derivative tests should not confuse us. An early diagnosis is essential, and early initiation of an anti-tuberculosis regimen can prevent the following complications. https://jhhhm.halal.ac.ir/article_176944_feed77dc5ff347cff76d15f77ebea01b.pdf