Halal Research Center of Islamic Republic of Iran.
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Email: jhhhm@halal.ac.ir
IR.MCIG No. 85915Human, Health and Halal Metrics2717-10272120210601Effects of sugar beet fiber and inulin on viability of Bifidobacterium bifidum and physicochemical and sensory properties of red grape juice11113310610.30502/jhhhm.2021.287783.1033ENFatemeh ZareiIran Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran.Leila NateghiDepartment of Food Science and Technology, Faculty of Agriculture, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran.0000-0001-8937-8728Journal Article20210525<strong>Background and objective</strong>: Dietary fibers are of prebiotic compounds which can increase viability of probiotic microorganisms in food products during storage and have healthful effects on the consumers. The aim of this study was to investigate the effect of different concentrations of inulin and sugar beet fiber on physicochemical and organoleptic properties of red grape juice and their stimulatory impact on viability of <em>Bifidobacterium bifidum</em> in the beverage.
<strong>Materials and methods</strong>: Amounts of 0.7, 1.4, and 2.1% w/v sugar beet fiber and 1, 2 and 3% w/v inulin were added to red grape juice inoculated with 10<sup>8</sup> CFU/ml <em>Bifidobacterium bifidum</em>. Viability of <em>Bifidobacterium bifidum </em>by enumeration on MRS agar<em>, </em>colorimetric evaluation, and study of sensory attributes by 5-points hedonic test were done on days 0, 5, 10, 15, 20, and 25. Moreover, pH and brix were determined during the storage time.
<strong>Results</strong> <strong>and conclusion</strong>: By increasing the concentration of inulin and sugar beet fiber, brix and pH of red grape juice increased and decreased, respectively. After 25 days of storage, the highest survival (7.05 log CFU/ml) was observed in the treatment containing 3% w/v inulin and 2.1% w/v sugar beet fiber and the least survival (5.03 log CFU/ml) was observed in control. Number of probiotic in all the treatments containing dietary fiber was higher than 10<sup>6</sup> CFU/ml after 25 days of storage, but lower than 10<sup>6</sup> CFU/ml was enumerated in control. The highest brightness and the least redness and yellowness was observed in control. By increasing the concentration of inulin above 1% w/v and sugar beet fiber above 1.4% w/v, palatability of grape juice samples decreased significantly. Therefore, red grape juice fortified with 1.4% w/v sugar beet fiber and 1% w/v inulin is a desirable beverage which can support survival of probiotic bacteria within the recommended range.Halal Research Center of Islamic Republic of Iran.
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IR.MCIG No. 85915Human, Health and Halal Metrics2717-10272120210815Qualification of the virgin olive oils sold in herbal stores of north of Iran121913512210.30502/jhhhm.2021.291535.1035ENZahra HesariDepartment of Pharmaceutics, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.Shirin ParvinrooDepartment of Pharmacognosy, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.0000-0003-4748-7007Fateme Haji KarimkhaniDepartment of Pharmacognosy, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.Abbas Naeimi KararoudiFood and Drug Research Center, Food and Drug Deputy, Guilan University of Medical Sciences, Rasht, Iran.Somayeh Ahmadi GoorajiDepartment of Biostatistics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Journal Article20210621<strong>Background and objective</strong>: Olive oil has a lot of nutritional and medicinal benefits, which make it more valuable than other oils. Therefore, it is noticeable for adulteration by mixing with the cheaper oils. At this study, authenticity of virgin olive oils sold in herbal stores in north of Iran (Rasht) has been investigated.<br /><strong>Material and methods</strong>: During 2019, 26 samples of virgin olive oils were collected randomly from the herbal stores of Rasht city (Guilan, north of Iran). Fatty acid profile by gas chromatograph, peroxide value by calculation of milliequivalent of active oxygen per kilogram of oil, and acidity by titration of the samples with potassium hydroxide were determined in the laboratory and compared to the national regulation.<br /><strong>Results and conclusion:</strong> Approximately, 58% of the samples were out of the permitted range at least in one of the measured parameters. With regard to fatty acid profile, 77% of the samples were within the normal range. Predominant fatty acids were included to oleic acid (59.8 ±14.3%), linoleic acid (21.4 ±14.1%), palmitic acid (13.8 ±1.4%), stearic acid (2.7 ±0.8%), and palmitoleic acid (0.7 ±0.3%). In case of peroxide value, 92.3% of the samples were within the acceptable range. Based on acidity, different virgin olive oils were differentiated as extra virgin (n = 1, %3.8), first grade virgin (n = 11, 42.31%), ordinary virgin (n = 8, %30.77), and lampante virgin (n = 6, %23.08). Our investigation revealed that the olive oils sold in herbal stores as traditional market should be monitored restrictedly to assess their originality and storage condition. Although, they should be examined periodically to find any adulteration, if exists.Halal Research Center of Islamic Republic of Iran.
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IR.MCIG No. 85915Human, Health and Halal Metrics2717-10272120210820Seed gum of basil (Ocimum basilicum L.) as a halal hydrocolloid affects technological and organoleptic properties of probiotic low-fat yogurt202613541110.30502/jhhhm.2021.294058.1036ENRoxana Molaei RoudsariDepartment of Food Science and Technology, Varamin Branch, Islamic Azad University, Varamin, Iran.Anosheh RahmaniDepartment of Food Science and Technology. Standard Research Institute. Karaj. Iran.Leila NateghiDepartment of Food Science and Technology, Varamin Branch, Islamic Azad University, Varamin, Iran.0000-0001-8937-8728Fatemeh ZareiIran Food and Drug Administration, Tehran, Iran.Journal Article20210708<strong>Background and objective: </strong><em>Ocimum basilicum</em>, generally identified as sugary basil, is a popular culinary herb. It contains functional oils such as chavicol, linalool, and eugenol, which are usually used in food and pharmaceutical industries. The aim of this study was evaluating the effect of basil seed gum on physicochemical and sensory attributes of low-fat probiotic yogurt.<br /><strong>Materials and methods: </strong>Effect of basil seed gum at concentrations of 0.1 and 0.2% w/w was studied in low fat probiotic yogurt during 1, 7, and 15 days. pH, acidity, viscosity, and dry matter were analyzed in the samples and compared to control. Sensory properties were included to color, texture, mouthfeel, and flavor.<br /><strong>Results and </strong><strong>conclusion:</strong> After addition of basil seed gum to the yogurts, pH of the samples was slightly lower than control. By increasing the concentration of gum, viscosity and dry matter were increased during storage. Analysis of sensory evaluation showed that the samples containing gum had significant differences in texture compared to control. Sensory properties were improved by addition of gum except for color which had the best score in control. The samples containing 0.1% w/w gum had significantly better flavor in comparison to the samples containing 0.2% w/w gum in which the best mouthfeel was found. The least score of mouthfeel was related to control, although the differences were not significant. Results showed that basil seed hydrocolloid has good potential to be used as fat replacer in food formula such as yogurt.Halal Research Center of Islamic Republic of Iran.
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IR.MCIG No. 85915Human, Health and Halal Metrics2717-10272120210830Evaluation of Conservative therapy in two groups of patients with low back pain associated with iliolumbar ligament enthesopathy and injury of muscles around hip in comparison with patients with other causes of low back pain273213597710.30502/jhhhm.2021.296829.1037ENHossein EttehadDepartment of Orthopedics, School of Medicine, Orthopedic Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.0000-0002-8049-7568Amir SalariDepartment of Orthopedics, School of Medicine, Orthopedic Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.0000-0002-8049-7568Mehran SoleymanhaDepartment of Orthopedics, School of Medicine, Orthopedic Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.Kamran EzzatiDepartment of Anatomy, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.Dalaleh KhososiGuilan University of Medical Sciences, Clinical Research Development Unit of Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.Journal Article20210726<strong>Background and objective: </strong>The most common problem in patients referred to orthopedic clinics is low back pain. Iliolumbar ligament enthesopathy is one of the causes of low back pain. In this study, we investigated the results of conservative therapy in two groups of patients<strong> </strong>with low back pain.<br /><strong>Materials and methods:</strong> This cross-sectional descriptive study was performed on 817 patients with back pain referred to our orthopedics clinic during 2013-2014. After diagnosis, patients were divided into two groups. Group A had pain with short external rotator muscles, iliolumbar ligament enthesopathy<strong> </strong>and gluteal muscle tenderness, and group B were presented with other causes of low back pain. After the end of the conservative therapy the Oswestry disability index were filled by subjects.<br /><strong>Results and conclusion:</strong> Of total, 303 patients (37.1%) were entered the group A and 514 patients (62.9%) were considered as group B with other causes of back pain. Out of 817 patients, 251 were males and 566 were females. The most common cause of pain was found to be discopathy with 438 cases (53.5%). The mean score of the Oswestry pain severity questionnaire was not statistically significant between 2 groups (P = 0.065) prior to the treatment. However, there was found a significant difference between the frequency distribution of the two groups according to the severity of the pain after the treatment (P = 0.0001). In conclusion, the results of our study indicated that the degree of disability, paraclinical cost, diagnosis based on the correct clinical examination in patients could be different, and patients with injuries such as iliolumbar enthesopathy and injured short extensor muscles around the hip and gluteus responded well to conservative therapy.Halal Research Center of Islamic Republic of Iran.
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IR.MCIG No. 85915Human, Health and Halal Metrics2717-10272120210912Capitolunate arthrodesis with scaphoid excision for the treatment of Scaphoid Nonunion Advanced Collapse wrists: a case-series333913663810.30502/jhhhm.2021.303493.1039ENAmir SalariOrthopedic Research Center, Department of Orthopedics, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.0000-0002-8049-7568Ahmadreza NezamslamiDepartment of Orthopedics and Trauma Surgery Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran.Reza Shahriyar KamraniDepartment of Orthopedics and Trauma Surgery Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran.0000-0002-8744-8515Journal Article20210906<strong>Background and objective:</strong> Scaphoid Nonunion Advanced Collapse (SNAC) is a common pattern of degenerative wrist arthritis. Besides the conventional surgical method (4-corner fusion (4CF)), alternative methods have been described as capitolunate arthrodesis. The objective of this study was to investigate the surgical result of the capitolunate fusion and the results from the post-surgical one-year follow-up.<br /><strong>Materials and methods:</strong> From March 2008 to March 2017, among 21 patients with SNAC wrist, stages 2 and 3, 14 were included. Following the scaphoid resection, by preserving capitate convexity and concavity of the lunate's distal face, the lunate was reduced on the capitate, and capitolunate fusion was done using Herbert screws, in the antegrade direction. All patients were followed for one year. Clinical examinations and wrist x-rays were investigated in each follow-up session. Visual analog score (VAS), Disability of the Arm, Shoulder, and Hand (DASH score) were compared before and after the surgery. Grip strength, flexion and extension were recorded one year after surgery, compared with intact non-operated hand.<br /><strong>Results and conclusion:</strong> Union occurred in all of the patients. VAS score and DASH score decreased (from 6.5 to 3.3 and from 46.14 to 30.43). The VAS score and DASH score decreased significantly after a one-year follow-up (<em>P</em>-value ≤ 0.05). Operated hand flexion was 34.30° (20-80), the extension was 32.58° (20-60), and grip strength was 29.69 Kg (22-40). Non-operated hand flexion was 56.38(30-80), the extension was 61.8 (38-80), and grip strength was 44.54 Kg (28-76). These differences were statistically significant (P-value ≤ 0.05). Based on our study results, scaphoid excision and capitolunate arthrodesis resulted in an acceptable functional wrist with minimal pain. This finding reflects that capitolunate arthrodesis is a time-saving and easy-to-learn procedure. Minimal morbidity of this method supports the idea that the capitolunate arthrodesis is an acceptable alternative to 4CF, the conventional surgical method.Halal Research Center of Islamic Republic of Iran.
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IR.MCIG No. 85915Human, Health and Halal Metrics2717-10272120210601Simultaneous determination of heavy metals in Tahini by anodic stripping voltammetry404513817210.30502/jhhhm.2021.288521.1034ENNaficeh SadeghiDepartment of Drug and Food Control, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.0000-0002-1613-1617Hassan Rezaei BehzadiDepartment of Drug and Food Control, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Masoomeh BehzadDepartment of Drug and Food Control, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.0000-0002-1613-1617Behrooz JannatHalal Research Center, Ministry of Health and Medical Education, Tehran, Iran.Mannan HajimahmoodiDepartment of Drug and Food Control, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.0000-0003-0006-6125Journal Article20210530<strong>Background and objective</strong>: Tahini is a regional dish prepared from sesame seeds and consumed as breakfast worldwide. It is a good source of zinc, copper, and group B vitamins. However, the product may be contaminated with toxic heavy metals. Therefore, our purpose was development of analytic method for simultaneous determination of zinc, copper, lead, and cadmium in Tahini.
<strong>Materials and methods:</strong> Our work was conducted on 37 brands of Tahini (n = 74). The samples were purchased from local market of Tehran (Iran). Concentration of heavy metals was measured by polarograph. Voltammetric analysis was carried out by using 746 VA trace analyzer by differential pulse anodic stripping Voltammeter at Hanging mercury dropping electrode.
<strong>Results and conclusion:</strong> Concentration of Zn, Cd, Pb, and Cu was calculated as 3.79 ±2.43, 1.48 ±0.08, 0.015 ±0.01, and 0.012 ±0.007 µg/100 g, respectively. Amount of Pb and Cd was lower than acceptable limit approved by CODEX in all the samples, while concentration of Cu and Zn was within the standard range. According to our investigation, Tahini can be used as a valuable food to meet the nutritional needs without any toxic effect arisen from deleterious heavy metals in the consumers.Halal Research Center of Islamic Republic of Iran.
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IR.MCIG No. 85915Human, Health and Halal Metrics2717-10272120211018Frequency of prolonged QT intervals in patients treated with methadone referred to an addiction treatment clinic in the north of Iran465113896210.30502/jhhhm.2021.304950.1040ENAboozar Fakhr-MousaviCardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.Amir SalariOrthopedic Research Center, Department of Orthopedics, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.0000-0002-8744-8515Azin VakilpourCardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.Seyed Mehdi MousaviCardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.Seyed Mahdi Zia ZiabariGuilan Road Trauma Research Center (GRTRC), Guilan University of Medical Sciences, Rasht, Iran.0000-0002-3708-7723Tolou HasandokhtSchool of Medicine, Guilan University of Medical Sciences, Rasht, Guilan, Iran.Fatemeh Salehi-NikCardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.Journal Article20210915<strong>Background and objective: </strong>Despite the benefits of methadone and its widespread use in opioid treatment programs, this drug has various adverse side effects even at therapeutic doses. This study aimed to determine the frequency of long QT intervals in patients treated with methadone with doses lower than 100 mg.<br /><strong>Materials and methods:</strong> In this cross-sectional study, all the patients between 30-65 years of age admitted for methadone maintenance treatment were enrolled. A matched group of patients with no history of using methadone was included. Screening electrocardiography was performed for all participants at the beginning. Demographic data, drug history, QT interval, and Maximum QTc time were evaluated. The mean QT interval was compared with the defined normal value using the one sample t-test. Also, the mean QT interval based on the methadone dose consumption and other variables was analyzed using t-test or ANOVA statistical tests. <em>P</em>-value less than 0.05 was considered significant. The statistical analysis was performed using SPSS version 18.<br /><strong>Results and conclusion:</strong> Out of 196 subjects, 97 patients were in the methadone group. 83.5% of methadone users and 68.7% of the control group were males. The mean age was 43.8, and 44.5 in the methadone and control group, respectively. 83.5% of methadone users and 68.7% of the control group were males. In the methadone group, 17.5% had abnormal QTc-Max, while only 2% of the control group had abnormal QTc-Max (<em>P</em>=0.0001). Of the people who consumed less than 40 mg of methadone daily, 3.7%, and those who consumed more than 40 mg, 34.9% experienced abnormal QTc-Max (P=0.0001). This survey revealed that methadone use in even doses lower than 100 mg could also increase the risk of QT prolongation. Therefore, the treatment team needs to be aware that arrhythmias might occur within a wide range of methadone treatment doses.Halal Research Center of Islamic Republic of Iran.
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IR.MCIG No. 85915Human, Health and Halal Metrics2717-10272120210610Halal edible biopolymers used in food encapsulation: a review526213437810.30502/jhhhm.2021.283062.1032ENZahra Khoshdouni FarahaniDepartment of Agriculture and Food Technology, Faculty of Food Science and Technology, Science and Research Branch University, Tehran, Iran.0000-0003-4254-0665Journal Article20210509<strong>Background and objective</strong>: Encapsulation is extensively used in food science and technology for protection of bioactive compounds by using several materials originated from different animals and plants. However, application of some of them is limited due to their suspicious halal origin. In this regard, gelatin is of concern for industrial application since it can be obtained from pork. At this review, we tried to investigate the halal biopolymers frequently used in food preparations.<br /><strong>Results and conclusion: </strong>Biopolymers have incredible impact in the formula as gelling, stabilizing, viscosifying, and coating agent. Other than the favorable roles of biopolymers, their origin is important by some countries to find out they are derived in accordance to halal concepts. Therefore, those derived from halal animals through the process which does not threat the halal status are accepted by Islamic countries. In such cases, alternative biopolymers such as agar, pectin, and carrageenan by similar features for the specific purpose should be used instead of gelatin derived from pork.Halal Research Center of Islamic Republic of Iran.
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IR.MCIG No. 85915Human, Health and Halal Metrics2717-10272120211005Methotrexate-induced neurocognitive late effects in treatment of pediatric acute lymphoblastic leukemia: a review637413888610.30502/jhhhm.2021.283539.1031ENMahdi TaherianGeneral Directorate of Natural, Traditional and Complementary Products, Iran Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran.0000-0003-4568-2837Zohreh TajabadiSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Arash AzhidehSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Reza TaherianSchool of Medicine, Hamadan University of Medical Sciences, Hamdan, Iran.0000-0002-5556-6904Journal Article20210429<strong>Background and objective</strong>: Childhood cancer survivors frequently experience long-lasting consequences of chemotherapy. Acute lymphoblastic leukemia is one of the most common malignancies that occur during childhood. By the help of new protocols, 5-year survival is about 80%. Despite all improvement in treatment and increasing surveillance, morbidities of these treatments are lifetime. The aim of this study was to review the recent updates on chronic neurologic deficits occurred by treatment of acute lymphoblastic leukemia, risk factors of these neurologic deficits, and prevention of their side-effects. Also, this review discusses the genetic variability in biochemical pathways targeted by chemotherapeutic agents as a possible mechanism contributed to psychopathology in acute lymphoblastic leukemia survivors.
<strong>Results and conclusion</strong>: The most important drug used for treatment of acute lymphoblastic leukemia is methotrexate. It is also the main drug for central nervous system prophylaxis. Most of chemotherapies drugs cannot pass blood brain barrier but methotrexate is an exception. Methotrexate is a double-edge sword, because it can pass blood brain barrier and can be used for central nervous system prophylaxis to decrease the relapses. On the other hand, it can cause chronic neurologic deficits as a result of its passage from blood brain barrier in the developing brain. In conclusion, prophylactic interventions during treatment (e.g., administration of leucovorin) and after treatment (e.g., cognitive training and maintenance of academic growth) are effective routes in prevention of late effects in survivors of acute lymphoblastic leukemia.